Leland H. Hartwell

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Leland H. (Lee) Hartwell (born October 30 1939, in Los Angeles, California) is president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. He won the 2001 Nobel Prize in Physiology or Medicine for his contributions to the understanding of the cell cycle through years of studying yeast. Co-recipients of the 2001 Nobel Prize in Physiology or Medicine were Paul Nurse and Tim Hunt, whose research focused on the cyclins and other aspects of cell division.

Hartwell received his bachelor's degree from the California Institute of Technology in 1961. In 1964, he received his PhD from the Massachusetts Institute of Technology. From 1965 to 1968, he worked at the University of California as a professor. He moved to the University of Washington in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the CDC (cell division cycle) genes in baker's yeast (Saccharomyces cerevisiae). These genes regulate the cell cycle and mutations in the genes are involved in some types of cancer.

In addition to the Nobel Prize, Hartwell has received many awards and honors. He became a member of the National Academy of Sciences in 1987. In 1998 he received the Albert Lasker Award for Basic Medical Research.

Dr. Hartwell is the Chairman of the Scientific Advisory Board at the Canary Fund, a non-profit organization dedicated to developing new technologies for the early detection of cancer.

References

Leland H. Hartwell, Joseph Culotti, and Brian Reid. Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants PNAS 1970 66: 352-359. Abstract (http://www.pnas.org/cgi/content/abstract/66/2/352)

External Links

pl:Leland H. Hartwell

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